This study looks at using natural progesterone, a hormone made by the body, to treat a type of brain cancer called recurrent glioblastoma. Researchers want to find the best dose and understand any benefits or side effects. Progesterone is thought to help slow down the growth and spread of cancer cells. In this study, patients will receive progesterone through a shot under the skin every day for up to 24 weeks, unless the cancer gets worse or side effects are too severe.

Key Points:

• Participants will need to get daily shots of progesterone for up to 24 weeks.
• The study checks if the cancer stays stable or gets better after 8 weeks.
• Eligibility includes being 18 or older, having certain blood levels, and not being on certain medications.

If you have questions about whether this study is right for you, talk to your doctor. They can help you understand the potential risks and benefits.