This study focuses on childhood cancer survivors to see if they might face health problems later in life due to their genes. These health problems include things like heart failure, bone damage, strokes, or even another cancer. By studying genes, researchers hope to find out who might be at risk. Genes are like special codes in our bodies that decide things like our hair color or can even affect our health. DNA and RNA are parts of these genetic codes.

To join the study, participants (cases) need to have had cancer diagnosed before age 21, and have experienced certain health problems after treatment. They will need to give a sample of blood or saliva for the study. There are also controls, who didn't experience these health problems but had cancer. They will also provide samples. Participants must be actively followed up by a Children's Oncology Group (COG) institution.

• Study might help predict future health risks for cancer survivors.
• Involves providing a blood or saliva sample.
• No extra treatments or medications are part of the study.