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An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene

Tracking Stargardt Disease Type 1 progression in patients through observation.

Recruiting
12-65 years
All
Phase N/A

Stargardt Disease Type 1 (STGD1) is a rare eye condition caused by genetic changes in the ABCA4 gene. This study aims to observe how STGD1 progresses over time. It is not a treatment study, but it helps researchers understand the disease better, which can guide future treatment studies. About 75 people will take part. Participants will not receive any new medicine, but their eye health will be monitored to see how the disease changes. This information helps in designing future treatment trials.

To join, you need to be between 12 and 65 years old, have STGD1 confirmed by a test, and have some vision loss from the disease. You should also have healthy eyes, other than the STGD1, to ensure good quality imaging. If you have other eye diseases, recent surgeries, or are taking certain supplements or medicines, you might not be eligible.

  • Study involves regular eye check-ups and imaging, but no new treatment.
  • Participants must be willing to stop certain supplements and medicines.
  • Eligibility includes age, genetic confirmation, and specific eye health criteria.
Study details
    Stargardt
    Stargardt's Disease
    Stargardt Disease
    STGD1

NCT06435000

Splice Bio

1 March 2025

Step 1 Get in touch with the nearest study center
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