The study focuses on total knee replacement surgery, which helps improve movement and lessen pain in people with severe knee arthritis. After surgery, patients often feel pain and nausea that can slow recovery. The study tests a medicine called glucocorticoids, specifically a type called Medrol Dose Pak, which helps reduce pain and swelling. It will compare this medicine with the usual care, which is a single dose of dexamethasone (a type of glucocorticoid). The study will last about 6 months and involve 200 patients undergoing knee surgery at Emory University. Patients will be randomly picked to get either the single dose or the dose followed by a 6-day Medrol treatment. The goal is to see if Medrol helps reduce pain, nausea, and the need for pain medicines called opioids.

• Study duration is approximately 6 months.
• Involves normal clinic visits and follow-ups at 1-day post-surgery and 7-10 days.
• 200 patients will be enrolled, 100 per treatment group.