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A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment

A study on new medicine for advanced breast cancer treatment options.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

Study Purpose: This study is exploring a new medicine called PF-07220060 combined with fulvestrant to treat advanced or metastatic breast cancer. Advanced cancer is hard to cure, and metastatic cancer has spread to other body parts. This study compares this combination to the doctor's choice of treatment.

Who Can Join: Adults (18+) with hormone receptor (HR)-positive and HER2-negative breast cancer that has progressed after previous treatments can join. Participants should not need medications that the study doesn’t allow and should be free of medical or mental conditions that may increase risks.

Study Details: Participants will receive treatment until their cancer worsens, the study doctor decides the treatment is not helpful, side effects are too severe, or they choose to stop. Half will take PF-07220060 and fulvestrant, while the other half will receive either fulvestrant alone or a combination of everolimus and exemestane.

  • Duration: Participants stay until certain conditions occur, like cancer worsening.
  • Visits: Regular scans like MRI or CT will monitor cancer progression.
  • Risks: Be aware of potential side effects, which are reactions to medicines.
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Study details
    Advanced or Metastatic Breast Cancer

NCT06105632

Pfizer

28 December 2024

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Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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