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Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

Join a study on early-onset Alzheimer's prevention and treatment options.

Recruiting
18-80 years
All
Phase 2/3

This study is about Alzheimer's disease, which is a condition that causes memory problems. It focuses on people with a specific type of Alzheimer's that is passed down through families due to a genetic mutation. This mutation is linked to early onset Alzheimer's, meaning it starts at a younger age.

The study is testing new treatments to see if they can slow down or improve symptoms. Participants might need to take a study drug or a placebo (a fake treatment for comparison). They will have tests like memory quizzes, brain scans (like MRI and PET), and fluid tests to check how the treatment is working.

  • The study lasts about four years, with regular visits for tests and assessments.
  • Participants may receive a new treatment, but they won't know if they are getting the real drug or placebo.
  • Travel may be required to a study site, and some costs might be covered.

Participants need to be between 18-80 years old and have a family history of this Alzheimer's mutation. The study is double-blind, meaning even the researchers don’t know who gets the real treatment to ensure fairness.

Study details
    Alzheimers Disease
    Dementia
    Alzheimers Disease
    Familial

NCT01760005

Washington University School of Medicine

12 October 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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