This study is for people with Stage IIIB/C melanoma, a type of skin cancer. The study is testing a treatment called Daromun. First, Daromun is injected directly into the tumor. After that, patients have surgery to remove the cancer, and then they get additional treatments to prevent the cancer from coming back. The study will see if this new method helps patients live longer without the cancer returning compared to just having surgery and additional treatments.

Melanoma is a dangerous skin cancer that can spread to other parts of the body. Daromun is a drug that is given directly into the tumor to try and shrink it before surgery. The study will compare two groups: one group receives Daromun plus surgery and extra therapy, and the other group receives only surgery and extra therapy. The study lasts up to six years to check if the cancer returns.

• The study involves two treatment groups and lasts up to six years.
• You will need to visit the hospital regularly for check-ups and treatments.
• You must meet specific health criteria to join the study.