This study investigates the effect of **Vagal Nerve Stimulation (VNS)** on people with **Opioid Use Disorders (OUDs)**. OUDs involve misuse or addiction to opioids, like prescription pain pills or heroin. VNS is a non-surgical procedure that uses a device to send mild electric pulses to the vagus nerve in the neck, which can help reduce opioid cravings and withdrawal symptoms. The study takes place over one week in a hospital, with a follow-up call 1-3 months later. Participants will have brain imaging and complete several tests, including psychiatric interviews and physiological monitoring.

• The study lasts about a week with one hospital stay.
• Participants will undergo brain imaging and follow-up calls.
• VNS is non-invasive and does not involve surgery.

To join, participants must have OUD, be willing to go through withdrawal, and transition to a treatment aftercare program. Some exclusions include pregnancy, certain medical conditions, and having an active implantable device like a pacemaker. This study is investigational and not yet FDA-approved for OUD treatment in the US.