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Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3

Exploring nerve stimulation for opioid use disorder treatment.

Recruiting
18-75 years
All
Phase 3

This study investigates the effect of **Vagal Nerve Stimulation (VNS)** on people with **Opioid Use Disorders (OUDs)**. OUDs involve misuse or addiction to opioids, like prescription pain pills or heroin. VNS is a non-surgical procedure that uses a device to send mild electric pulses to the vagus nerve in the neck, which can help reduce opioid cravings and withdrawal symptoms. The study takes place over one week in a hospital, with a follow-up call 1-3 months later. Participants will have brain imaging and complete several tests, including psychiatric interviews and physiological monitoring.

  • The study lasts about a week with one hospital stay.
  • Participants will undergo brain imaging and follow-up calls.
  • VNS is non-invasive and does not involve surgery.

To join, participants must have OUD, be willing to go through withdrawal, and transition to a treatment aftercare program. Some exclusions include pregnancy, certain medical conditions, and having an active implantable device like a pacemaker. This study is investigational and not yet FDA-approved for OUD treatment in the US.

Study details
    Withdrawal Symptoms
    Opioid Use Disorder
    Opioid Use

NCT05834478

Emory University

15 March 2025

Step 1 Get in touch with the nearest study center
Entire USA
Results (undefined sites found)
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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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