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A Study to Investigate the Safety and Pharmacological Effect of a Single Intravenous Infusion of Belantamab in Male and Female Participants Aged 18 to 75 With Autoimmune Disease

Testing belantamab infusion safety for lupus in adults 18-75.

Recruiting
18-75 years
All
Phase 1

This study looks at the safety of a medicine called belantamab, given through an IV (intravenous, meaning directly into a vein) to people aged 18 to 75 who have moderate to severe systemic lupus erythematosus (SLE). SLE is a disease where the body's immune system attacks its own tissues, causing inflammation and damage. The study will measure how belantamab affects the body and how its levels change over time. Participants need a body mass index (BMI) of 18 to 32, and a weight of at least 40 kg (about 88 pounds). A positive test for anti-dsDNA, a marker of lupus, is also required.

  • Study Length: This is a single infusion study, meaning you will receive the medicine only once.
  • Visits Needed: You may need to visit the clinic for check-ups to monitor your health and the medicine's effects.
  • Risks: Those with severe lupus flares or unstable health conditions may not qualify.

Make sure to talk to your doctor to see if participating is a good choice for you.

Study details
    Autoimmune Diseases

NCT06413511

GlaxoSmithKline

15 March 2025

Step 1 Get in touch with the nearest study center
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  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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