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Association of Plant-based Diet and Gut Microbiome Signature with Response to Neoadjuvant Therapy in Pancreatic Ductal Adenocarcinoma

Exploring plant-based diets' effects on treatment response in pancreatic cancer.

Recruiting
18 years and older
All
Phase N/A

This study looks at how a plant-based diet affects people with pancreatic ductal adenocarcinoma (**PDAC**), a type of pancreatic cancer. It focuses on how diet and gut microbiome (the bacteria living in your stomach) impact the success of chemotherapy given before surgery, called **neoadjuvant therapy**. The study is observational, meaning you only complete surveys and provide a fecal sample; no experimental treatment is given. The study aims to see if the variety of gut bacteria or a healthy diet, measured by the **HEI-2015** dietary score, can predict a better response to treatment.

Key Points:

  • Participants must be 18 or older and diagnosed with resectable PDAC.
  • The study requires a dietary survey and a sample of feces.
  • Excludes those with advanced PDAC or who have had chemotherapy.
Study details
    Borderline Resectable Pancreatic Ductal Adenocarcinoma
    Resectable Pancreatic Ductal Adenocarcinoma
    Stage I Pancreatic Cancer AJCC V8

NCT06595160

Emory University

13 December 2024

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