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LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

LEGEND Study: Testing EG-70 in certain bladder cancer patients.

Recruiting
18 years and older
All
Phase 1/2

The LEGEND Study is testing a new treatment called EG-70 for people with bladder cancer. Bladder cancer is when bad cells grow in the bladder, which is the organ that holds urine. EG-70 is a special kind of treatment known as gene therapy, which is designed to help the body fight the cancer right where it is, in the bladder. This study has two parts: Phase 1 checks if EG-70 is safe and Phase 2 checks how well it works.

In the study, patients who have tried a treatment called BCG but it didn't work, or who haven't had enough BCG, can join. BCG is a therapy that helps the body fight cancer. People in the study will get the EG-70 treatment for about one year, with regular check-ups to see how they are doing.

  • Participants will undergo up to four 12-week cycles of EG-70 treatment.
  • There are eligibility requirements related to previous cancer treatments and health conditions.
  • Patients must be willing to follow all the study rules and give consent to participate.
Study details
    Superficial Bladder Cancer
    Non-muscle Invasive Bladder Cancer With Carcinoma in Situ

NCT04752722

enGene, Inc.

15 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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