This study is about finding the best way to treat a pulmonary embolism (PE), which is a blood clot in the lungs. It compares two treatments: blood thinners alone and blood thinners with the EkoSonicTM device, which helps dissolve clots. Participants will be randomly assigned to one treatment and followed for a year. They will have check-ups in the hospital, and at 7 days, 30 days, 6 months, and 12 months after starting. The study looks to see which treatment reduces the risk of death or serious problems.

• The study lasts for 12 months with several follow-up visits.
• Participants must be between 18-80 years old and have a confirmed PE.
• Some people, like those with severe bleeding issues, can't join for safety reasons.

Participants will need to sign a consent form to join. The results will help doctors understand the best way to treat PE. The study uses a computer system to keep track of all the data, ensuring it is accurate and complete. This information will help improve PE treatment in the future.