Study Summary: This study is for people with colorectal cancer that has spread to up to 4 places in the body. It compares two treatments: one is the usual systemic therapy (medications that go through your blood to reach the cancer), and the other adds total ablative therapy (specific treatments aimed to destroy cancer at the spread sites) to the usual therapy. Ablative therapy includes focused radiation called stereotactic ablative radiotherapy (SABR), surgery, and microwave ablation (using heat to kill cancer cells). The goal is to see if adding these treatments helps patients live longer and if it affects the cancer's return or side effects.

• The study lasts for several months, with regular check-ups and scans like CT, MRI, or PET/CT.
• Participants may receive additional focused treatments like SABR, surgery, or microwave ablation.
• Participation involves a commitment to attend regular medical visits and undergo various tests.

Eligibility: To join, you must have metastatic colorectal cancer with no more than four spread sites and meet other specific health criteria. Pregnant or nursing women cannot participate. Participants must be 18 years or older and have stable health according to the study's requirements.