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Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

Join our study for cancer with KRAS G12C mutation.

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18 years and older
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Phase 1/2
KRYSTAL-1 Study Summary

Study Overview: This research is testing a new drug called MRTX849, also known as adagrasib, for people with certain types of advanced cancer. The cancer must have a specific change in its genes called a KRAS G12C mutation. The goal is to see if the drug is safe and how well it works.

What does the study involve? Adagrasib is taken by mouth in pill form. The study will look at how the drug behaves in the body, what happens to it over time (pharmacokinetics), and its effects on the body (pharmacodynamics). Researchers will also check for any side effects and see if the cancer responds to the treatment.

Who can join? You can participate if you have a confirmed diagnosis of a solid tumor with the KRAS G12C mutation and if other standard treatments are not an option. You must have good organ function and no other active cancers.

  • Study Length: Phase 1/2, early-stage study, specific duration not mentioned.
  • Visits Needed: Regular check-ups and monitoring required.
  • Risks: Possible side effects from the medication.
Study details
    Advanced Cancer
    Metastatic Cancer
    Malignant Neoplastic Disease

NCT03785249

Mirati Therapeutics Inc.

13 December 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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