The TAPUR study looks at using FDA-approved drugs for patients with advanced-stage cancer. These drugs target specific changes in tumor genes that might make the cancer respond to treatment. The study is non-randomized, which means everyone involved knows what treatment is given, unlike some studies where treatments are given randomly.

Participants must be at least 12 years old and have a type of cancer that cannot be helped by standard treatments. They also need to have good organ function and measurable cancer. Patients with brain tumors or certain other conditions are not eligible.

The study requires participants to have results from a special lab test showing specific changes in their cancer genes. This helps doctors decide if a targeted drug might work for them.

• Participants need a genomic test to see if they qualify.
• The study accepts patients with advanced cancer with specific genetic changes.
• Patients must agree to use birth control during the study.

For more information, visit www.tapur.org/news or contact TAPUR@asco.org.