Estradiol Therapy in Transgender Women to Research Interactions with HIV Therapy

This study looks at how estradiol, a hormone therapy, affects HIV medicine in transgender women. Transgender women (TW) are people who were assigned male at birth but identify as female. Estradiol is used for feminizing hormone therapy (FHT), helping TW develop female characteristics. Some worry that HIV medicines, called antiretroviral treatment (ART), might not work well with estradiol. This can make people skip their ART, which can increase the HIV virus in their body.

The study lasts 48 weeks and involves 90 TW living with HIV. Participants will continue their ART and receive estradiol. There are three groups based on the type of ART they use. The study checks if ART works well while taking estradiol and how different doses of estradiol interact with ART.

• Study lasts for 48 weeks.
• Participants will receive estradiol while continuing their ART.
• Regular check-ups are necessary to monitor drug interactions.

To be part of the study, participants need to be 18 or older, identified as TW, and on certain HIV medicines without plans to change during the study.