This study is looking at a new medicine called **plozasiran** to help adults with a condition called *severe hypertriglyceridemia* (SHTG). SHTG means having very high levels of triglycerides, which are a type of fat in your blood. The study will test if plozasiran is safe and if it works well. Participants will get either plozasiran or a placebo (a pretend medicine that doesn't do anything) every three months for a year. After that, they might get a chance to keep taking plozasiran in another study.

• Study Length: 12 months with an option to continue
• Visits: Must attend several appointments for tests and treatment
• Risks: Possible side effects from the medicine

To join, you must have recent medical records showing high triglyceride levels (500 mg/dL or more) and meet other health requirements. Some people can't join, like those using certain other medicines or having specific health conditions. If you qualify and choose to join, you'll help researchers learn more about treating SHTG.