Primary sclerosing cholangitis (PSC) is a rare liver disease that harms the bile ducts. These are tiny tubes that help move bile, a liquid from the liver, to the small intestine. Bile helps us digest and use nutrients from our food. In PSC, bile gets stuck in the liver, leading to damage and scarring. This study focuses on kids with PSC to understand more about the disease's progress, find out what might speed it up, and see how it affects daily life.

The study will collect information and samples like DNA from children with PSC. This will help researchers find out more about the causes and long-term effects of PSC. The study will also look at how PSC affects children's lives and explore new imaging techniques to see the liver's condition better.

• The study includes children ages 2-25 with PSC and lasts several years.
• Participants will need to visit clinical sites and share medical information and samples.
• Participants must not have had previous liver transplants or certain other medical conditions.