Study Summary: This research is for people with Systemic Lupus Erythematosus (SLE), a disease where the immune system attacks the body. The study is testing a medicine called ESK-001 to see if it is safe and helps treat SLE. Some people will get ESK-001, and others will get a placebo, which is a fake treatment that looks like the real thing but has no medicine in it. This helps scientists see if the medicine really works.

Study Length: The study lasts about 57 weeks, starting with a 5-week screening, followed by 48 weeks of treatment, and a 4-week follow-up. After finishing, participants may join an open-label extension where everyone gets ESK-001.

• Participants must have had SLE for more than 6 months and meet specific criteria.
• Participants must be on certain treatments like low-dose steroids or antimalarial drugs.
• Participants must not have other serious health issues that could affect the study.

Key Points: The study requires a long commitment (over a year), includes multiple visits, and participants may get a placebo. Discuss potential risks with your doctor before joining.