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Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

Testing Nivolumab and Ipilimumab for INI1-negative cancers in young patients.

Recruiting
6-40 years
All
Phase 2

This study is for children and young adults with certain cancers called INI1-negative tumors. The study is looking at two drugs, nivolumab and ipilimumab, that help the immune system fight cancer. These drugs are called immunotherapy drugs. This is a Phase II trial, which means it checks if the drugs are safe and if they work for this type of cancer. The U.S. Food and Drug Administration (FDA) has approved these drugs for other diseases, but not for the specific cancers in this study.

Here are some key points to consider:

  • Duration & Visits: The study might involve frequent hospital visits for tests and treatments.
  • Eligibility: Participants must have specific types of tumors and meet health requirements.
  • Risks and Safety: The drugs are being tested, so there are unknown risks, and participants will be monitored closely.

If you decide to join, you will need to meet certain health standards, and you cannot participate if you're pregnant or have certain other health issues. Participants will need to follow specific guidelines, including using birth control during and after the study.

Study details
    Malignant Rhabdoid Tumor
    Rhabdoid Tumor of the Kidney
    Epithelioid Sarcoma
    Chordoma (Poorly Differentiated or De-differentiated)
    Atypical Teratoid/Rhabdoid Tumor
    Other INI1 Negative Tumors (With PI Approval)
    Other SMARCA4-deficient Malignant Tumors (With PI Approval)

NCT04416568

Dana-Farber Cancer Institute

12 October 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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