Study Purpose: This study looks at a new way to give insulin for adults with Type 1 diabetes. We want to see if sending insulin straight to the liver helps reduce low blood sugar (also called hypoglycemia) when compared to regular insulin shots.

How It Works: Participants will be split into two groups. One group will get liver-targeting insulin (HDV-Insulin Lispro), and the other group will use their regular insulin (Insulin Lispro). Both groups will also use Insulin Degludec, a type of long-acting insulin. The study lasts up to 32 weeks, which includes several periods for screening and adjusting insulin doses.

Eligibility:

• Must be between 18 and 80 years old with Type 1 diabetes.
• Use of certain insulins and a Continuous Glucose Monitor (CGM) is required.
• Cannot be pregnant or using certain medications.

Things to Consider:

• The study lasts about 32 weeks with several visit requirements.
• You will need to use specific insulin and a CGM device provided by the study.
• There may be risks, such as low blood sugar or reactions to insulin.