This study compares two types of radiation therapy for liver cancer: **proton therapy** and **photon therapy**. Proton therapy uses a beam of proton particles to target tumors and might cause less harm to nearby healthy organs than photon therapy, which uses high-energy x-rays. The study will check if proton therapy helps liver cancer patients live longer than photon therapy. It will also look at how the cancer grows, side effects, and overall quality of life for patients. Participants will be randomly assigned to receive one of the two treatments over 15-24 days. After treatment, they will be followed up every 3 months for 2 years, then every 6 months for 3 more years.
- Study Duration: 5 years follow-up after the treatment period.
- Visits: Regular follow-ups every 3 months for the first 2 years, then every 6 months for the next 3 years.
- Treatment: Proton or photon therapy over 15-24 days.
Patients with liver cancer that cannot be removed by surgery may join if they meet specific health criteria. Participants must not have tumors outside the liver or uncontrolled other cancers. Women who could get pregnant must use birth control. Talk to your doctor to see if this study is right for you.