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Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

Testing BMS-986393 CAR T therapy for tough multiple myeloma cases.

Recruiting
18 years and older
All
Phase 2

Study Summary: This study aims to test the safety and effectiveness of a new treatment called BMS-986393 for people with multiple myeloma, a type of cancer affecting blood cells. The treatment is a special kind of therapy called CAR T Cell Therapy. This means scientists take some of your immune cells, change them to better fight cancer, and put them back in your body.

Key Points:

  • The study is for adults whose multiple myeloma has come back or has not responded to past treatments.
  • You need to have had at least four types of treatments before and must have a performance status of 0 or 1, which means you are fully active or have some activity restrictions.
  • If you join, you cannot have certain infections or past treatments targeting a specific protein, GPRC5D, without a rest period.

Before joining, ensure you are ready for multiple visits and tests. Talk with your doctor to see if this is a suitable option for you. Remember, this study is focused on people who have tried several treatments already without success. Always consider the potential benefits and risks with your healthcare provider.

Study details
    Multiple Myeloma

NCT06297226

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

1 February 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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