NEXUS Aortic Arch Clinical Study is investigating a new device, the NEXUS™ Aortic Arch Stent Graft System, designed to treat sections of the aorta, a large blood vessel in the body. The aortic arch is a curved part of the aorta. The study is prospective (looking forward), non-randomized (participants are not randomly selected), and multi-center (conducted at multiple locations). This study aims to check the safety and effectiveness of the NEXUS™ system for treating thoracic aortic lesions, which are problems or injuries in the aorta. Participants should be at least 18 years old and have specific conditions related to the aorta. Certain medical situations like acute dissection (tear in the inner layer of the aorta) or recent heart attacks exclude participation. The study involves undergoing a procedure and attending follow-up visits. Eligible participants must be able to follow the study instructions.

• Study involves a procedure and follow-up visits.
• Participants must be at least 18 years old.
• Specific aorta conditions required for eligibility.