Image

An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

Evaluating long-term safety of Eplontersen for heart condition ATTR-CM.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is looking at how safe a medicine called eplontersen is for people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). ATTR-CM is a heart problem caused by a build-up of harmful proteins. The study will involve around 1,400 people who will get eplontersen once every four weeks for up to three years. They will also take vitamin A daily. The study has three parts: a screening period, a treatment period, and a follow-up period.

  • This study lasts up to 3 years with medicine given every 4 weeks.
  • Participants must take vitamin A every day.
  • Only people who finished an earlier related study or have ATTR-CM can join.
Print
Study details
    Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

NCT05667493

Ionis Pharmaceuticals, Inc.

13 December 2024

Contact a study center
Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

  Other languages supported:

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.