This study looks at treating nasal and paranasal sinus cancer that can be removed with surgery. It compares two methods: chemotherapy before surgery and radiation therapy versus just surgery and radiation. Chemotherapy uses special drugs like docetaxel, cisplatin, and carboplatin to stop cancer cells from growing or spreading. Radiation therapy uses strong x-rays to kill cancer cells. The idea is to see if adding chemotherapy before surgery can make the tumor smaller and help keep more healthy tissue.
Key points to consider:
- The study involves random assignment to one of two treatment plans.
- Participants have follow-up visits every 3 months for up to 2 years, then every 6 months up to 5 years.
- Eligibility includes being fit for surgery and having specific cancer stages.
Important: Women must not be pregnant, and both men and women should use contraception during the study. Participants must not have other major health issues or allergies to the treatment drugs. The study checks frequently on patient health and treatment progress with MRI or PET/CT scans.