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Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery

Exploring treatment options for nasal and sinus cancer with surgery.

Recruiting
18 years and older
All
Phase 2

This study looks at treating nasal and paranasal sinus cancer that can be removed with surgery. It compares two methods: chemotherapy before surgery and radiation therapy versus just surgery and radiation. Chemotherapy uses special drugs like docetaxel, cisplatin, and carboplatin to stop cancer cells from growing or spreading. Radiation therapy uses strong x-rays to kill cancer cells. The idea is to see if adding chemotherapy before surgery can make the tumor smaller and help keep more healthy tissue.

Key points to consider:

  • The study involves random assignment to one of two treatment plans.
  • Participants have follow-up visits every 3 months for up to 2 years, then every 6 months up to 5 years.
  • Eligibility includes being fit for surgery and having specific cancer stages.

Important: Women must not be pregnant, and both men and women should use contraception during the study. Participants must not have other major health issues or allergies to the treatment drugs. The study checks frequently on patient health and treatment progress with MRI or PET/CT scans.

Study details
    Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7
    Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7

NCT03493425

ECOG-ACRIN Cancer Research Group

4 January 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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