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A Study of TSC-100 and TSC-101 in AML, ALL and MDS Patients Undergoing Haploidentical Donor Transplantation

Exploring new treatments for AML, ALL, and MDS with donor transplants.

Recruiting
18 years and older
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing new treatments called TSC-100 and TSC-101 for patients with certain types of blood cancer: AML (Acute Myeloid Leukemia), MDS (Myelodysplastic Syndromes), and ALL (Acute Lymphoblastic Leukemia). These treatments are given after a patient receives blood stem cells from a family donor who is a half-match (haploidentical donor). TSC-100 and TSC-101 are special T cells made in a lab to help fight cancer. The study aims to find out if TSC-100 and TSC-101 are safe and to see how well they work.

Key Points:

  • The study will last for up to 2 years with follow-up visits to check for side effects and effectiveness.
  • Participants will receive standard cancer treatment plus TSC-100 or TSC-101, depending on their specific needs.
  • There are some risks, such as side effects from the new treatment, and patients will be closely watched.

Participants need to be at least 18 years old, agree to follow-up visits, and have a specific genetic type to join. They will also need a family donor who matches certain criteria. This study is an opportunity for those who meet the requirements to try new treatments that could improve their health.

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Study details
    AML
    Myelodysplastic Syndromes
    ALL
    Adult

NCT05473910

TScan Therapeutics, Inc.

1 February 2025

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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