PREFER Study Summary: This study is collecting blood and tissue samples from people with advanced cancers like lung, breast, and prostate cancer. The goal is to identify certain mutations, which are changes in the DNA, using an OmniSeq test that helps doctors decide on the best treatments. Next-generation sequencing, a method to read DNA, is used to find these mutations.

The study focuses on helping minority and underserved groups by collecting samples that represent different ethnicities. The samples are stored in a biorepository, a special place for keeping biological materials for research. This helps scientists understand cancer better and develop new drugs.

Participants need to be at least 18 years old and will not undergo extra procedures since samples are collected during routine care. The study ensures privacy by not including personal identifiers.

• Study Duration: No additional visits; samples collected during routine care.
• Participation Benefits: Contributes to future cancer treatment and understanding.
• Risks: Minimal as no extra medical procedures are involved.