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Testing the Safety of Adding Either Monalizumab (IPH2201) or Oleclumab (MEDI9447) to Durvalumab (MEDI4736) Plus Standard Radiation Therapy for Locally Advanced Non-small Cell Lung Cancer (NSCLC), ARCHON-1 Trial

Testing new lung cancer treatments with Monalizumab or Oleclumab and radiation.

Recruiting
18 years and older
All
Phase 1

This study is for people with a type of lung cancer called non-small cell lung cancer (NSCLC) that has spread nearby but not to other parts of the body. It's testing a treatment that combines radiation therapy (using high-energy rays to kill cancer cells) with immunotherapy (helping the immune system fight cancer). The medications tested are durvalumab, monalizumab, and oleclumab, which are special proteins called monoclonal antibodies designed to fight cancer cells. This trial aims to see if adding these medications makes the cancer treatment safer and more effective. The trial involves regular check-ups, scans, and blood tests. Participants will receive treatment every 4 weeks for up to 13 cycles and will be followed up for 2 years.

  • Length of Study: Active treatment for about 1 year, then follow-up for 2 years.
  • Visits Needed: Frequent doctor visits for treatments and check-ups.
  • Risks: Possible side effects from medication and radiation.
Study details
    Locally Advanced Lung Non-Small Cell Carcinoma
    Locally Recurrent Lung Non-Small Cell Carcinoma
    Stage II Lung Cancer AJCC v8
    Stage III Lung Cancer AJCC v8
    Unresectable Lung Non-Small Cell Carcinoma

NCT03801902

National Cancer Institute (NCI)

13 December 2024

Step 1 Get in touch with the nearest study center
Entire USA
Results (undefined sites found)
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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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