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A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)

Evaluating Mezigdomide with other drugs for recurring multiple myeloma.

Recruiting
18 years and older
All
Phase 3

This study is testing a new medicine combination for people with relapsed or refractory multiple myeloma (RRMM), a type of cancer affecting white blood cells. The study will compare two treatment options: Mezigdomide with carfilzomib and dexamethasone (MeziKD) versus only carfilzomib and dexamethasone (Kd). Mezigdomide is an experimental drug being tested to see if it works better with the other two drugs.

To join, you need to have multiple myeloma with measurable disease, have tried other treatments before, and your cancer must have returned or not responded to those treatments. You cannot join if you've had certain transplants or if you've been treated with mezigdomide or carfilzomib before.

  • The study involves comparing two different drug treatments.
  • You must have tried other cancer treatments before joining.
  • Previous treatment with mezigdomide or carfilzomib disqualifies you.

If you have questions or want to join, talk to your doctor to see if this study could be right for you.

Study details
    Relapsed or Refractory Multiple Myeloma

NCT05552976

Bristol-Myers Squibb

15 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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