This study tests a vaccine to help the body fight against HIV, a virus that attacks the immune system. The vaccine includes a protein called N332-GT5 gp140 and small particles called SMNP, which help the body respond better to the vaccine. The study checks if this vaccine is safe and how well it works in healthy adults who do not have HIV. Participants will receive the vaccine through shots in the arm in different ways to find the best method. This study involves 84 volunteers aged 18-55 and lasts for 22 months, with 8 months for signing up and checking on participants' health.

• Participants will visit the clinic several times over 22 months.
• Volunteers must be healthy, aged 18-55, and agree to follow study rules.
• There's a risk of side effects from the vaccine, like in any medical study.