Atovaquone Combined with Radiation in Children with Malignant Brain Tumors is a study testing a medicine called atovaquone with radiation therapy to see if it helps treat certain brain tumors in kids. Atovaquone is a drug already approved by the FDA (the agency that makes sure medicines are safe) to treat infections. Now, researchers think it might help fight cancer too. Some brain tumors are very hard to treat, but early studies show that atovaquone might help shrink tumors and help radiation work better. The study looks at kids who have just been diagnosed or those whose cancer has come back. Kids need to be 2 to 25 years old and weigh more than 10 kg (about 22 pounds) to join. They also need to have good liver and organ health. Some kids with stable seizures can also participate. If a child has ever had an allergic reaction to atovaquone, they can't join. The study might take several weeks, and children will get regular check-ups to see how the treatment is working.

• The study is for children aged 2 to 25 with specific brain tumors.
• Participants receive atovaquone with radiation therapy.
• Children must meet health criteria to join.