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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Testing blood thinners for new irregular heartbeats after heart surgery.

Recruiting
18 years and older
All
Phase 3

This study looks at how adding a blood thinner, called an anticoagulant, can help or hurt people who have a type of irregular heartbeat called atrial fibrillation (AF) after heart surgery known as coronary artery bypass graft (CABG). AF is when the heart beats out of rhythm, and CABG is a surgery to help blood flow to the heart. The study aims to see if taking an anticoagulant along with regular blood thinner pills can prevent blood clots but also wants to check if it increases the chance of major bleeding.

People in the study will either take the blood thinner pills alone or with an anticoagulant for 90 days. If AF happens more than once within 7 days after surgery, they may join the study. The study will take place over 60 months, with check-ins at 30, 60, 90, and 180 days. Up to 500 patients might wear a heart monitor for 30 days.

  • Participating involves taking medications for 90 days.
  • Regular check-ups will be required.
  • There is a risk of bleeding with treatment.
Study details
    Atrial Fibrillation
    Stroke
    Bleeding

NCT04045665

Icahn School of Medicine at Mount Sinai

16 February 2025

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