We are conducting a study to test a new treatment called zilebesiran. This treatment is for people with high cardiovascular risk (serious heart-related problems) and hypertension (high blood pressure) that is not well managed by usual medicines. Participants should have a history of heart disease, are at high heart risk, or have a moderate kidney function level. They also need to have high blood pressure and be on 2 to 4 blood pressure medicines already.

Some people cannot join, like those with secondary hypertension (high blood pressure caused by another condition) or serious kidney issues. The study will help us see if zilebesiran works better when added to current therapies.

• The study will require regular visits to the clinic.
• Participants will be compensated for their time and travel.
• The study involves taking zilebesiran in addition to your current medications.