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Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases

Exploring radiation timing with surgery for brain metastases treatment.

Recruiting
18 years and older
All
Phase 3

This study looks at treating people with cancer that has spread to the brain, called brain metastases. It compares two treatments: one where patients get stereotactic radiosurgery (SRS) before surgery, and one where they get it after. SRS is a special type of radiation that targets only the cancer in the brain, leaving normal brain tissue safe. This study will help doctors understand if giving SRS before surgery might be better for stopping tumor growth and improving symptoms.

  • Participation involves surgery and one session of SRS, either before or after surgery.
  • The study lasts for about two years with regular follow-ups.
  • Participants must be 18 or older, able to have surgery and SRS, and must not have had prior brain radiation at the surgery site.

To join, you need to have 1-4 brain metastases, one of which needs surgery. Your cancer should not be near the brain's sensitive parts like the brainstem or optic chiasm. You must be healthy enough for surgery and SRS and agree to use contraception during the study if needed. Past treatments like whole brain radiation could exclude you. This research helps find the best way to use surgery and radiation together for brain metastases.

Study details
    Metastatic Malignant Neoplasm in the Brain

NCT05438212

NRG Oncology

15 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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