This study is for people with Atrial Fibrillation (AF), a condition causing irregular heartbeats. It's testing a drug called abelacimab against a placebo (a "fake" drug with no active ingredient) to see if it can prevent ischemic strokes (when blood can't reach the brain) or systemic embolism (when a blood clot moves to other parts of the body). The study is for people who can't take regular blood thinners because of bleeding risks or other issues.

To join, you should be 65 or older, have AF, and have a high CHA2DS2VASc score (a way to measure stroke risk). You can't join if you have certain other health issues, like recent strokes or certain blood conditions.

• **Study Length:** Varies per individual, discuss with the study team.
• **Visits:** Regular medical check-ups are required.
• **Compensation:** May be provided, check with the study team.

This study could help find safer treatments for people with AF who can't take regular medication, but make sure to discuss any potential risks with your doctor.