This study is for people with a brain cancer called glioblastoma multiforme (GBM). The patients being studied have a specific type of GBM that doesn't have a chemical marker called MGMT. The study aims to see if a new treatment called TVI-Brain-1 immunotherapy works better than the usual treatment alone. In this study, the patient's own cancer cells are turned into a vaccine to help the body fight the cancer. This vaccine helps increase special cells called T cells in the body, which can attack the cancer. These T cells are taken from the blood, grown in a lab, and then given back to the patient.

Key Points:

• Patients must have this specific type of GBM and no previous treatment.
• The treatment involves surgery, vaccine creation, and follow-up visits including MRIs.
• No treatment with steroids allowed before getting the vaccine and T cell infusion.