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Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma

Testing Epcoritamab with Rituximab and Lenalidomide for follicular lymphoma safety.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

Follicular Lymphoma (FL) is a type of cancer affecting white blood cells called lymphocytes. This study tests if a new drug, epcoritamab, works well with other medicines, rituximab and lenalidomide, in adults whose FL has returned or not responded to treatment. Epcoritamab is an experimental drug, which means it's still being tested. Participants will be split into three groups, with about 500 people taking part worldwide. They will receive different combinations of the medicines for up to 12 cycles, each lasting 28 days. One group is no longer accepting new participants.

Participants will have regular hospital visits for checks, including medical exams, blood tests, and questionnaires. The study may require more hospital visits than regular care. Doctors will look for changes in the disease and any side effects from the treatment.

  • The study lasts for up to 12 cycles (28 days each).
  • Participants will have regular medical visits and tests.
  • There might be more treatment visits than usual care.
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Study details
    Follicular Lymphoma (FL)

NCT05409066

Genmab

11 January 2025

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