This study looks at two treatments for people with a heart problem called non-valvular atrial fibrillation (AF). AF can raise the risk of a stroke, which happens when blood flow to the brain is blocked. The study compares the Amulet LAA occluder, a device that blocks a part of the heart where clots can form, to a type of medicine called NOAC (novel oral anticoagulant) that prevents clots. People in the study will be randomly placed into two groups: one will use the device, and the other will take the NOAC medicine.

• Participants need to be able to follow the required medicine or device treatment plan.
• The study involves regular check-ups and is conducted in many places around the world.
• Participants must be 18 or older and able to give written consent to join the study.

People with certain health conditions, like a recent stroke or heart surgery, or those who are pregnant, cannot join. If you have questions or think you might be eligible, talk to your doctor to learn more.