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Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD

Testing COMP360 for safety and effectiveness in treating depression.

Recruiting
18 years and older
All
Phase 3

Study Overview: This study is testing a new treatment called COMP360 for people with treatment-resistant depression (TRD). TRD means the depression hasn't improved with other treatments. The study is international and includes people aged 18 and older. Participants will be randomly chosen to receive either COMP360 or a placebo (a pill with no medicine) and will get support from a therapist.

The study has three parts and lasts about 62 weeks. The first part (Part A) is six weeks long and checks how well the treatment works compared to the placebo. Part B lasts 20 weeks and looks at long-term effects and if re-treatment works. Part C is 26 weeks and gives the treatment openly without placebo.

  • Participation lasts up to 62 weeks, with several parts and check-ups.
  • You must be 18 or older with TRD to join.
  • Some mental health conditions and treatments may exclude you from participating.

Note: Discuss with your doctor before deciding to join, as the study involves a long commitment and certain health considerations.

Study details
    Treatment Resistant Depression

NCT05624268

COMPASS Pathways

17 December 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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