Image

A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Study on how Mavacamten affects heart structure in certain patients.

Recruiting
18 years and older
All
Phase 4
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at how a medicine called mavacamten affects the heart's muscle in adults with a heart problem called obstructive hypertrophic cardiomyopathy (oHCM). oHCM means the heart muscle is too thick, making it hard for blood to leave the heart.

To be part of the study, you must have oHCM, with a heart condition class II or III by the New York Heart Association (NYHA). Your heart's blood flow, called the left ventricular outflow tract (LVOT), must be blocked by at least 30 millimeters of mercury (mmHg) and even more after exercise. Your heart should also pump well, with a left ventricular ejection fraction (LVEF) of 55% or higher.

If you have other heart problems, like coronary artery disease, had a heart attack, or have a pacemaker, you cannot join. The study uses cardiac magnetic resonance imaging (CMR) to see changes in the heart.

  • This study requires several visits for imaging tests.
  • Participants should be comfortable with MRI scans.
  • Discuss any heart devices with your doctor before joining.
Print
Study details
    Cardiomyopathy
    Hypertrophic

NCT06112743

Bristol-Myers Squibb

15 March 2025

Contact a study center
Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

  Other languages supported:

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.