The PEERLESS II Study is looking at a treatment called the FlowTriever System, which is used along with blood thinners to help people with a condition known as intermediate-risk acute PE. PE stands for pulmonary embolism, which is a blood clot in the lungs. This study is testing whether using the FlowTriever System works better than just using blood thinners alone.

• This study involves using a device to help remove clots from the lungs and requires taking blood thinners.
• You need to be 18 years or older and have certain health conditions to join.
• If you have certain heart or lung conditions or are pregnant, you may not be able to join.

If you decide to participate, you will be randomly assigned to receive either the FlowTriever System plus blood thinners or just blood thinners. This study can help doctors find better ways to treat PE. Before joining, make sure you understand the risks and benefits, and discuss with your doctor if you have any questions. Also, you should be willing and able to sign a consent form, confirming you understand and agree to participate in the study.