This study is testing a new medicine called Ponsegromab for people with heart failure. Heart failure is when the heart can't pump blood as well as it should. The study compares Ponsegromab to a placebo, which is a fake injection that looks like the real medicine but doesn't have any active ingredients. Participants won't know if they're getting the real medicine or the placebo. Most people in this study will get an injection under the skin every four weeks for about nine months, visiting the study clinic monthly. Some people in a special group will only get Ponsegromab and will be in the study for about seven months.

Key Points:

• Study lasts about 9 months for the main group, with monthly clinic visits.
• Participants receive injections every four weeks.
• There's a special group that only gets the study medicine for 7 months.

Before joining, participants must be 18 or older and have specific medical conditions. Some people can't join, like those who've had a heart transplant or certain recent surgeries. Participants also shouldn't have taken similar investigational medicines before.