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Gemcitabine, Cisplatin and Nab-Paclitaxel As Neoadjuvant Treatment for Patients with Resectable or Borderline Resectable Pancreatic Cancer

Study on chemotherapy for treatable pancreatic cancer before surgery.

Recruiting
18 years and older
All
Phase 2

This study is testing a treatment plan for pancreatic cancer that can be removed by surgery. The treatment uses three drugs: gemcitabine, cisplatin, and nab-paclitaxel given before surgery, which is called neoadjuvant therapy. These drugs are chemotherapy medicines. Gemcitabine stops cancer cells from making DNA, which is needed for them to grow. Cisplatin is a platinum-containing drug that kills cancer cells, while nab-paclitaxel stops cancer cells from dividing. The goal is to see if using these drugs before surgery helps patients live longer. Patients will receive the drugs through a vein (IV) on specific days and will be monitored for two years after treatment.

  • Treatment lasts for up to 4 cycles, each cycle being 28 days long.
  • Patients must be adults and able to follow the study schedule.
  • There are specific health criteria to join, such as good blood counts and no major health problems.

Patients will have regular check-ups to monitor their health and cancer status. It's important to understand that there are risks, like side effects from the drugs, and not everyone will be eligible to participate.

Study details
    Borderline Resectable Pancreatic Ductal Adenocarcinoma
    Resectable Pancreatic Adenocarcinoma
    Stage I Pancreatic Cancer AJCC V8
    Stage II Pancreatic Cancer AJCC V8
    Stage III Pancreatic Cancer AJCC V8

NCT06423326

Emory University

13 December 2024

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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