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Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

Genetic testing for certain lung cancer patients before or after surgery.

Recruiting
18 years and older
All
Phase N/A

This study is for patients with a type of lung cancer called non-small cell lung cancer (NSCLC), which has been or will be removed by surgery. The study looks at the genes in the cancer cells to help doctors choose the best treatment. The main goal is to test for genetic changes in the cancer to help find new treatments.

Key points:

  • Participation involves genetic testing and possibly receiving different types of treatments.
  • The study may last up to 5 years with regular follow-ups every 6 months.
  • Patients may receive compensation if participating in treatment trials.

Patients need to provide blood and tissue samples for testing. The study checks for changes in specific genes such as EGFR, ALK, and PD-L1, which may influence treatment options. If you have surgery before joining the study, your previous tissue samples will be used for testing. The study also observes how lung cancer changes over time and how these changes affect treatment. Eligibility includes being 18 or older, having a specific stage of cancer, and not having had certain treatments before. Women who are pregnant or breastfeeding cannot join. This study could help improve future lung cancer treatments by finding targeted therapies.

Study details
    Stage IB Lung Non-Small Cell Carcinoma AJCC v7
    Stage II Lung Non-Small Cell Cancer AJCC v7
    Stage IIA Lung Cancer AJCC v8
    Stage IIB Lung Cancer AJCC v8
    Stage IIIA Lung Cancer AJCC v8
    Stage IIIA Lung Non-Small Cell Cancer AJCC v7
    Stage IIIB Lung Cancer AJCC v8

NCT02194738

National Cancer Institute (NCI)

16 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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