This study looks at how a new eye drop called Miebo® affects people with dry eye disease (DED) over 12 months. DED is when your eyes don’t make enough tears or the right kind of tears, which can lead to discomfort. The study will measure something called corneal endothelial cell density (ECD). These cells are important for keeping your eyes clear. The study is randomized and double-masked, meaning participants will be randomly given either the study eye drop or a placebo (fake solution), and neither they nor the researchers will know who has which until the end.

• Length: This study lasts for 12 months.
• Participation: You'll need to stop wearing contact lenses during certain times.
• Eligibility: You must be at least 18 years old and have a certain level of eye health.

This study involves regular visits to the study center, where your eye health will be checked. It's important to know that you might not get the Miebo® eye drops, as some participants will receive a placebo instead.