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A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

Exploring daratumumab treatments for AL amyloidosis patients in a study.

Recruiting
18 years and older
All
Phase 2

Amyloid Light Chain (AL) Amyloidosis is a condition where abnormal proteins, called amyloids, build up in tissues and organs, affecting their function. This study involves using Daratumumab, a medicine usually for blood cancers, combined with other drugs to understand its safety on the heart in people with AL amyloidosis. The study has two parts: one looks at heart safety, and the other focuses on how the medicine works in different racial groups.

Key Points:

  • The study involves multiple visits and tests over time.
  • Participants may receive compensation for their time and travel.
  • There could be side effects, especially related to the heart.

To join, participants need to have certain health conditions, like heart involvement, and meet other health criteria. This study is not for those who have had certain treatments or other health issues like multiple myeloma. If you are eligible and considering joining, you should discuss it with your doctor to understand the benefits and risks.

Study details
    Amyloidosis

NCT05250973

Janssen Research & Development, LLC

9 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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