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Phase 2 DoceRamPem for Patients with Metastatic or Recurrent NSCLC Who Progressed on Platinum-Doublet and PD-1/PD-L1 Blockade

Trial for advanced lung cancer after certain treatments haven't worked.

Recruiting
18 years and older
All
Phase 2

This study is testing a combination of three drugs for people with a type of lung cancer called non-small cell lung cancer (NSCLC). These patients have not responded well to previous treatments. The drugs used are: Pembrolizumab, which helps the immune system attack cancer; Ramucirumab, which stops new blood vessels from feeding tumors; and Docetaxel, which stops cancer cells from dividing. Pembrolizumab is a PD-1 checkpoint inhibitor, meaning it helps keep the immune system active against cancer cells. The study aims to see if this new combination works better than current treatments.

  • Participation Requirements: Visits every 21 days, with regular check-ins for up to 10 years to monitor the effects.
  • Compensation: Details on compensation are not specified, but participants may benefit from potential improvements in their condition.
  • Potential Risks: Side effects may occur, and participants will be closely monitored for their safety.
Study details
    Metastatic Non-Small Lung Cell Cancer
    Recurrent Non-Small Lung Cell Cancer
    Stage IV Lung Cancer AJCC V8
    Stage IVA Lung Cancer AJCC V8
    Stage IVB Lung Cancer AJCC V8

NCT04340882

Emory University

2 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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