This study looks at the safety of a medicine called cytisinicline for helping adults who smoke regular cigarettes or e-cigarettes to quit. Cytisinicline is a medicine taken three times a day, every day, for about a year (52 weeks). It is for those who joined earlier studies called ORCA-2, ORCA-3, or ORCA-V1 and still smoke or use e-cigarettes daily. To join, you must agree to start taking cytisinicline the day after you join and try to quit smoking within two weeks. You also need to take part in quit-smoking support sessions.
Some people can’t join, like those allergic to the medicine, with certain health problems like heart attacks or severe kidney issues, or women who are pregnant. Participants will have regular check-ups to see how they are doing.
- Study lasts for about 1 year with regular health check-ups.
- You must have been in certain previous studies to join.
- Not suitable for people with certain health conditions or pregnant women.