This study examines advanced penile cancer treatments. Patients are split into groups based on the size and spread of their cancer. There are three initial treatments: A. standard surgery (called ILND - removing lymph nodes in the groin), B. chemotherapy and then ILND, or C. chemoradiotherapy (chemotherapy plus radiation) followed by ILND. After surgery, doctors check if cancer might come back. Patients at high risk may get more treatment, called PLND, which removes more lymph nodes.

• Eligibility: Patients must have a specific type of penile cancer, no cancer spread to other organs (M0 stage), and be in good health.
• Exclusion: Patients with other cancers or who had past treatments like chemotherapy can't join.
• Study Details: The study is international, involves random assignments, and helps doctors decide the best treatment sequence.

Participation involves multiple steps and treatments, but it aims to find the best way to treat advanced penile cancer and help future patients.